The film tells the story of Fan Jingya who devotes herself to researching medical solutions for the treatment of Amyotrophic lateral sclerosis for her son. Boss Chen takes advantage of her to develop a highly intelligent mutant Sharktopus, which leads to a huge disaster. Everyone is trapped on a cruise ship, and Fan Jingya and Lu Fei work together to lead everyone in a battle of wits and courage with the Sharktopus. A battle royale between humans and beasts begins....